Core Facility Biomolecular Interactions and Crystallography

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The core facility provides services leading to the biophysical and structural characterization of biomolecules and to the study of (bio)molecular interactions.  It is equipped with the instrumentation to perform a complete X-ray crystallography experiment of biomolecules and their complexes, basic characterization of physical properties of the molecules (analytical ultracentrifugation, analytical size-exclusion chromatography, dynamic light scattering, CD spectroscopy, differential scanning calorimetry, differential scanning fluorimetry), and to study thermodynamics and/or kinetics of interactions (isothermal titration calorimetry, surface plasmon resonance, bio-layer interferometry, microscale thermophoresis, analytical ultracentrifugation).


  • Complementary techniques for molecular interactions studies

  • Detailed analysis of macromolecular properties: homogeneity, stability, oligomeric state 

  • 20 individual machines utilizing 14 principally different biophysical techniques in one facility

  • Complex crystallography services: set-up of screening and optimization plates, automatic inspection of crystals with​ UV imaging, X-ray diffraction, structure solution


The Core Facility is part of the Czech National Center of European Research Infrastructure Consortium INSTRUCT ERIC under the Czech Infrastructure for Integrative Structural Biology (CIISB) funded by the Ministry of Education, Youth and Sports of the Czech Republic. CF BIC members are actively involved in an open pan-European network Association of Resources for Biophysical Research in Europe (ARBRE).