News:


SPR instrument Biacore S200 installed

16. 9. 2022

This week, we installed a new SPR machine. Biacore S200 (by Cytiva) is the top-level four-channel biosensor with higher sensitivity compared to the current T200 machine allowing for analysis of the smallest molecules as well as hard-to-obtain ligands. The machine, which is equipped with newly developed operation and data analysis software, will be operated in user mode.

For more details on instrument usage, please contact Josef Houser.



NanoTemper Seminar: Meet the expert - CANCELLED

6. 9. 2022

Dear users, 

for technical reasons on the NanoTemper site, the planned short seminar with the company application specialist has been canceled. Thank you for your understanding.



SPR instrument Alto - demo

26. - 28. 7. 2022

SPR instrument ALTO from Nicoya will be available in CF BIC laboratory as a demo. There shall be a possibility to discuss the instrument features in more detail with a company representative on Tue 26th afternoon.  

If you are interested in meeting Alto more closely, please, let us know at bic@ceitec.cz



New CF BIC head

1.7.2022

From the 1st July 2022, Josef Houser has been installed as a new CF head. Michaela Wimmerová stays in the CF as an advisor and mentor.​




Long-term demo of Imaging System Odyssey M

30.5.2022

Dear Users, 

The Odyssey M as a long-term demo is available in our laboratory. It fills the role of a Western blot imager, plate reader, slide scanner, fluorescence, and luminescence imager. Perform membrane-, plate-, gel-, and slide-based assays–all on one system. Resolution up to 5 µm. More details about the system can be found on the web page.

Ask for the initial training via the booking system



Installation of the new MicroCal PEAQ-ITC Automated

11. - 14. 4. 2022

Dear users,

due to the installation of the new ITC device, the ITC service will not be available from the 11th to 14th of April. Thank you for your understanding. 

CF BIC team



New CF BIC video on YouTube
1. 3. 2022

Are you new to the field of biomacromolecules? Do you want to find more about what is the mission of CF BIC in the world of science? A  short video for a broad audience was made to introduce our aims and abilities. Chech the CEITEC YouTube channel for more information on what is going on in the Core Facilities and Research.  



NanoTemper Workshop: 

Measure binding affinities and characterize your protein with NanoTemper Technologies

14. - 15. 3. 2022

Dear users, 

CF BIC and NanoTemper are organizing the workshop on the field of protein characterization and biophysical measurements, namely nanoDSF, DLS and MST. Monolith X system and PR.Panta instruments will be available for hands-on session. Detailed information with workshop program is available HERE.

Registration for free via e-mail bic@ceitec.czC



Methods for Characterization of Biomolecular Interactions: Classical versus modern
1. - 2. 2. 2022

Dear users, 

we are organising workshop, which should be attended by structural biologists and biochemists who want to improve their knowledge of current methods for characterisation of interactions between biomacromolecules and their ligands including proteins, nucleic acids as well as small molecules. Workshop consists of 2 days of Lectures given by Biomolecular Interactions and Crystallization Core Facility staff. It is open to anyone upon
registration via e-mail bic@ceitec.cz

Please, see more information on the flyer.




Christmas Hollidays

22. 12. 2021 - 3. 1. 2022

CF BIC will be completely closed during the Christmas holidays from Dec 22 till Jan 3, 2022. Access to the laboratory from Dec 20 till Dec 21 will be possible for techniques in user mode after the previous agreement with the CF BIC responsible person.

Thank you for understanding and we wish you Merry Christmas and Happy New Year!

CF BIC



Cleaning in CF BIC laboratories

12. - 17. 12. 2021

Dear users,

please, check all your articles stored in CF BIC laboratories, especially in refrigerators, and remove everything you would like to maintain till Fri December 10. Laboratories will be carefully cleaned during the week of December 12 - 17, old samples will be disposed of. 

Thank you for your cooperation



Limited access to the CF BIC laboratories

30. 11. 2021

Dear CF BIC users,

due to the attendance of CF BIC members on Jaroslav Koča Memorial Colloquium on Computational and Structural Biology,  the measurements and services will be limited on Tuesday, November 31st.

Thank you for understanding.



AQS3pro Microfluidic Modulation Spectroscopy

9. 11. 2021

The first lecture "An introduction to MMS" is opened up to the capacity of room C04/1S57, Tuesday, Nov 9th from 9:00. 

The AQS3pro is a spectroscopic secondary structure analysis tool for protein characterization. The technology is designed for five key measurements—protein aggregation, quantitation, stability, similarity, and structure. The demo will be available on the 9 - 11 of November 2021. In case of interest, please, contact Monika Kubíčková.  




CF Day Meeting

21. 10. 2021

Join us during CF Day, where all eleven CEITEC MU Core Facilities will be presented. CF BIC is scheduled at 10 a. m. Registration on-site till October 5th, on-line still open. More information HERE.



Closure of CF BIC laboratories

​​14. 9. 2021

Due to the shooting of CF BIC presentation movie, no measurement will be possible on the 14th of September 2021. We apologize for any inconvenience.



CF BIC member in the management of ARBRE

​​ 1. 7. 2021

Our member Josef Houser was elected to the Board of Directors of the Association of Resources for Biophysical Research in Europe (ARBRE). The association stimulates collaboration and sharing of know-how between biophysical core facilities in order to offer high-quality services and develop the methodology. For more information, check the ARBRE websites.



Operation of CF BIC during summer 2021

​​29. 6. 2021

Access to all CF BIC services will be limited during the summer, machines in user mode shall be accessible as usual but with limited support on-site and reduced availability of training.

AUC and ITC services will not be available on August 16th - 31st

Crystallization and SEC-MALS services will be limited throughout summer

For further details, contact the CF responsible person directly or via  bic@ceitec.cz.

Have a great summer! ​




Buffer screen article has been published

30. 5. 2021

In our facility, we have developed a 48-condition buffer screen for protein stability assessment. It is suitable for buffer optimization focusing on thermal stability (DSF), homogeneity (DLS), or activity (BLI, SPR) studies. The screen is available as ready-to-use solutions in a plate. Check out more in the published paper here.



Crystallization equipment transfer

18. 12. 2020

From Jan 2021, all the crystallization equipment of CF BIC is being transfered to C04 building (formerly A4) of the University campus Bohunice. Also new plate storages and imagers were installed. The crystallization services shall be available again from the end of January. For details, please contact CF BIC team.




New booking table

7. 12. 2020

New booking table has been released on December 7th. In the case of problems with the functionality, please, read the manual or contact us.





User meeting

1.12.2020

We cordially invite you to join us for CF BIC User meeting on December 8th at 15 p.m. via MS Teams.

Please, fill in our QUESTIONNAIRE.



OMNISEC GPC/SEC system

1.11.2020

New OMNISEC GPC/SEC system was successfully instaled and is available in a service mode. For more details see the manufacturer page at https://www.malvernpanalytical.com/en/products/product-range/omnisec



Building renumbering

14.10.2020

Please note that the buildings of the UKB (University campus Bohunice) have been renumbered. Our main location is now building C04 (formerly A4), the crystallization equipment is located in E35 (formerly A35).





Workshop Open SPR

25.9.2020

Workshop Uncover your binding kinetics with Open SPR, formerlz planned for November 3rd 2020, had to be POSTPONED due to pandemic restrictions. New date will be anounced depending on the epidemic situation.

REGISTRATION will be available HERE.