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ABOUT CF BIC:

The core facility provides services leading to biophysical and structure characterization of biomolecules and to study (bio)molecular interactions.  It is equipped with the instrumentation to set up crystallization conditions of biomolecules and their complexes, basic characterization of physical properties of the molecules (analytical ultracentrifugation, dynamic light scattering, CD spectroscopy, differential scanning calorimetry, differential scanning fluorimetry), and to study thermodynamics and/or kinetics of interactions (isothermal titration calorimetry, surface plasmon resonance, microscale thermophoresis, CD spectroscopy, analytical ultracentrifugation).


UNIQUE FEATURES:

  • Set-up of crystallization screens using commercial-available kits
  • Automatic inspection of crystals  - remote access to results for users
  • UV imaging to distinguish a protein from a salt
  • Set-up of optimization screens
  • Estimation of the precipitation diagram
  • Production of crystals for structural determination
  • Quality improvement of crystals for structural determination
  • Isothermal titration microcalorimetry
  • Differential scanning calorimetry
  • Surface plasmon resonance
  • Particle size analysis
  • Analytical ultracentrifugation
  • Microscale Thermophoresis
  • Differential scanning fluorimetry
  • Circular dichroism spectroscopy, fluorescence measurement



The Core Facility is part of Czech national centre of European Research Infrastructure Consortium INSTRUCT ERIC under the Czech Infrastructure for Integrative Structural Biology (CIISB) funded by the Ministry of Education, Youth and Sports of the Czech Republic, and a member of an open pan-European network Association of Resources for Biophysical Research in Europe (ARBRE). The Core Facility is also funded from INTERREG and CIISB4HEALTH projects.

        

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